Yucca Health Review

• Three commitment tiers per treatment, with the billed amount and the monthly equivalent both published
• Four published lines under one clinician relationship: GLP-1, GLP-1 + GIP, NAD+ and sermorelin
• Licensed providers in all 50 US states; medications prepared by state-licensed US pharmacies
• Full refund at any point before a clinician issues the prescription, and a full refund including the consultation fee if a clinician declines to treat you
• Plans can be paused indefinitely, keeping the enrolled price, as long as the next order has not reached the pharmacy
• Free UPS 2-Day Air shipping; certificate of analysis on request (checked 19 September 2026)

Compounded semaglutide and compounded tirzepatide for weight management, NAD+ positioned for longevity, and sermorelin positioned for muscle recovery, each with its own page, its own price tiers and its own intake. Yucca states its compounded medications "contain the same active pharmaceutical ingredients (APIs) as brand-name drugs", are "prepared by licensed U.S. pharmacies", and "are not FDA-approved, and do not undergo FDA review for safety, effectiveness, or manufacturing quality". No pharmacy is named. Its own FAQ answers the question of what is available with semaglutide and tirzepatide only, and does not mention the other two.

An online intake reviewed by a licensed provider, which Yucca says happens within 24 hours. Yucca states plainly that no live appointment is needed, so there is no video consultation at any point.

Free shipping, stated as UPS 2-Day Air, with a certificate of analysis available on request.

Yucca prices every treatment three ways, and the difference between them is commitment rather than dose. On compounded semaglutide the six-month plan is $750 billed every six months, which Yucca shows as $125 a month; the three-month plan is $420 billed every three months, shown as $140; and the month-to-month plan is $146 with no commitment. On compounded tirzepatide the same structure runs $1,350 every six months ($225 a month), $744 every three months ($248), and $258 month-to-month. Every figure was read from Yucca's own treatment pages on 19 September 2026, and the monthly equivalents are arithmetic on the billed amounts rather than a separate offer.

Two things follow that the headline figures hide. The billed amount is what leaves your account: a $125 semaglutide plan is a single $750 charge, not six payments. And the flexible route is not much dearer per month but is meaningfully dearer per year: $146 against $125 is about $250 over twelve months, and $258 against $225 is about the same. Yucca states that plans renew automatically at whatever interval you chose until you pause or cancel.

NAD+ and sermorelin are priced on two tiers rather than three, with no six-month option. NAD+ is $475 billed every three months, shown as $158 a month, or $215 month-to-month. Sermorelin is $475 every three months for 90 injections, also shown as $158, or $199 month-to-month for 30. Sermorelin is the only treatment whose tiers state how many injections you receive.

Alongside the weight-management line Yucca sells two peptides with their own pages, their own prices and their own intake quizzes: NAD+, which it positions under "Longevity", and sermorelin, which it positions under "Muscle Recovery". They are not add-ons to a GLP-1 plan. Each is enrolled separately, and the longevity and recovery intakes are distinct from the weight-loss one.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in energy metabolism and cellular repair whose levels are thought to decline with age, which is why it appears so often in longevity marketing. Sermorelin is a synthetic analogue of growth-hormone-releasing hormone: it prompts the pituitary to release more of the body's own growth hormone rather than supplying growth hormone itself, so it is not HGH therapy and should not be read as equivalent to it. Sermorelin also sits on the WADA prohibited list, which matters for any athlete subject to testing. Neither is an approved anti-ageing or body-composition medicine, the human evidence behind the claims made around both is limited, and Yucca's own FDA disclosure, that its compounded medications are not FDA-approved and have not been reviewed for safety, effectiveness or manufacturing quality, applies to them as it does to the GLP-1 line.

Two gaps are worth noting before enrolling on either. Yucca's own FAQ answers "what medications are available through Yucca Health?" with semaglutide and tirzepatide only, and does not mention these two at all. And the "Yucca 6-Month Promise" refund commitment is explicitly limited to GLP-1 injectable weight-loss plans, so it does not cover a peptide plan. Whether either treatment is appropriate for you is a decision for the prescribing clinician, not a directory.

More on these treatments: How NAD+ injection and nasal spray prices compare across US providers · How sermorelin prices compare across US providers

One line decides whether you can get your money back: whether a clinician has issued your prescription. Before that point Yucca states you can cancel at any time for a full refund, "no fees, no questions". After it the order is final, in Yucca's words, "whether the medication is being compounded, has been compounded, or has shipped, the order cannot be cancelled and is non-refundable". The reason it gives is the one that constrains every provider in this segment: a compounded medicine is prepared for one named patient at one dose and cannot lawfully be dispensed to anyone else. If a clinician declines to treat you, Yucca states the refund is automatic and total, including the consultation fee.

Cancelling a plan is separate from cancelling an order. Yucca states that cancellation stops future charges but does not refund charges already processed or orders already in progress, and that you must cancel at least seven days before a renewal date to stop the next cycle. It offers pausing as the alternative: a paused plan is not charged, can be paused indefinitely as long as the next order has not gone to the pharmacy, and keeps the price you enrolled at.

That price lock is worth reading before you switch anything. Yucca promises the enrolled price for as long as enrolment stays active, including as the dose is titrated upward, but it attaches to one medication on one billing cadence. Moving between medications, or between monthly, quarterly and six-month billing, starts a new plan at whatever price is current, and returning later does not bring the old lock back. Cancelling ends it outright. Yucca also publishes a "6-Month Promise" refund commitment, which it describes itself as "a commercial satisfaction commitment, not a medical guarantee"; it applies only to GLP-1 injectable weight-loss plans started on or after 18 September 2026, and this page makes no claim about outcomes on the strength of it.

PCF reviews online programs for comparison purposes only. Provider details, pricing, availability, and medication paths can change. Confirm current terms directly and consult a licensed clinician before making medical decisions.