MOTS-c dosage calculator
Enter the milligrams in your MOTS-c vial, the bacteriostatic water added and the dose your prescriber set, and this returns the concentration, the volume to draw in mL and the units on a U-100 insulin syringe. Arithmetic only: it does not suggest a dose and publishes no dosing chart. MOTS-c is not FDA approved, and any dose is the prescriber's decision.
Calculator
The dose your prescriber set. The opening figure is an example for the arithmetic, not a dose.
The opening 100mcg is an arbitrary placeholder for the arithmetic, not a dose. MOTS-c is not FDA approved, and any dose is set by the prescriber.
Draw to
2units
on a U-100 insulin syringe (0.02 ml)
- Concentration
- 5 mg/ml
- 5000 mcg/ml
- Volume to draw
- 0.02 ml
- Doses per vial
- 100
- Syringe capacity
- 30 units
How this is calculated
concentration (mg/ml) = vial mg / water ml = 10 / 2 = 5 concentration (mcg/ml) = concentration mg/ml x 1000 = 5000 volume to draw (ml) = dose mcg / concentration mcg = 100 / 5000 = 0.02 insulin units = volume ml x 100 = 0.02 x 100 = 2 doses per vial = floor(water ml / volume ml) = floor(2 / 0.02) = 100 100 units = 1 ml on every U-100 insulin syringe. Barrel size changes how much it holds, never what a unit means.
How MOTS-c is supplied
MOTS-c comes as a lyophilised (freeze-dried) powder in a sealed vial, and the label states the milligrams of peptide in it, for example 5mg or 10mg, and nothing about volume, because there is no liquid until bacteriostatic water is added. Two vials of the same strength can therefore give very different figures on a syringe: a 10mg vial with 2ml of water is 5 mg/ml, and the same vial with 4ml is 2.5 mg/ml, so the same dose occupies twice the volume and twice the units.
The figure in the dose field when the page opens, 100mcg, is an arbitrary placeholder chosen to make the arithmetic easy to follow. It is not a dose and is not based on any amount people use. The dose comes from the prescriber: replace the placeholder with the dose on your prescription, in mcg or mg, and check the units figure against the syringe you have: the calculator flags a figure that does not fit in one draw.
Why there is no MOTS-c dosage chart here
Dosage charts for MOTS-c circulate widely online, and none of them comes from an approved label, because there is no approved product. MOTS-c is not FDA approved, and as of mid-2026 no completed human trial of administering it had been published: the evidence for its effects is mostly preclinical, from cell and animal studies. A chart of milligrams and schedules built on that evidence would be a guess presented as a reference.
A dose is the prescriber's decision for one patient. What this page can do reliably is the arithmetic between that dose and the syringe, and it shows its working so the figures can be checked against the pharmacy's preparation instructions. MOTS-c is also on the World Anti-Doping Agency prohibited list, banned in sport at all times.
MOTS-c and the October 2026 US policy
Under an interim HHS policy announced on October 28, 2026 and published in the Federal Register on October 30, 2026, state-licensed 503A pharmacies may compound MOTS-c acetate on a patient-specific prescription, as the only active ingredient, for subcutaneous or intramuscular injection only, if the policy's conditions are met. HHS says the policy does not grant FDA approval or establish safety and effectiveness, and that it may revisit it. A product that blends MOTS-c with another peptide is outside it. Nothing changes outside the US.
Our guide to the October 2026 US peptide policy sets out its conditions, and the MOTS-c peptide page covers what the research does and does not show. For any other vial, the peptide calculator does the same arithmetic and has a full reconstitution chart.
Frequently asked questions
How many units is a milligram of MOTS-c?
It depends on how much water is in the vial. From a 10mg vial with 2ml of water (5 mg/ml), each milligram is 0.2ml, which is 20 units on a U-100 syringe. With 1ml of water (10 mg/ml) each milligram is 10 units, and with 4ml (2.5 mg/ml) it is 40 units, more than a 0.3ml syringe holds. Scale that by the dose on your prescription, which comes from the prescriber; without the water volume there is no fixed answer.
Is there a MOTS-c dosage chart or a dosage per week?
Not one we will publish. MOTS-c is not FDA approved, there is no approved label to read a dose from, and the evidence for administering it is mostly preclinical. A dose and how often it is given are the prescriber's decision. This calculator converts the dose you were given into mL and units; it does not suggest one.
How much bacteriostatic water for a MOTS-c vial?
Where a pharmacy dispensed the vial, use the volume it states. Otherwise the volume is a choice that sets the concentration: more water spreads the same dose over more units, which is easier to read, and less water concentrates it into fewer. The calculator shows what each volume does to your figure and whether it fits your syringe.
Can MOTS-c be prescribed in the US?
Under an interim HHS policy announced on October 28, 2026, a licensed US prescriber can order MOTS-c acetate compounded by a state-licensed 503A pharmacy for one patient, as the only active ingredient, for subcutaneous or intramuscular injection, under the policy's conditions. It is still not FDA approved, HHS may revisit the policy, and MOTS-c remains banned in sport.
Does a 5mg or 10mg vial change the dose?
No. The dose is the amount of peptide; the vial strength and the water decide how many units that amount occupies. With the same water, a 10mg vial is twice as concentrated as a 5mg vial, so the same dose is half the volume and the vial lasts twice as long.
Before you use this
This tool performs arithmetic only. It does not recommend a dose, a frequency, a duration or a supplier. Many peptides discussed online are not approved by the FDA for the uses people describe. Compounded medicines are supplied on prescription and should be prepared exactly as your pharmacy instructs. Talk to a prescriber or pharmacist before preparing or administering anything.